研究领域

侯尚国课题组主要从事多维生物动态成像方向研究。研究方向包括：

1. 多维动态光学显微成像技术开发；

2. 病原体与宿主相互作用机制；

3. 定量生物分子动态成像；

4. 人工智能生物成像。

成果

侯尚国博士的研究领域为高时空分辨光学显微成像技术开发及其在生物体系中的应用。针对不同尺度的分子和细胞体系，发展了一系列的多光学维成像方法，用于研究各种不同体系和条件下的生物分子与细胞之间的相互作用。研究成果以通讯以及第一作者身份发表在Nature Communications、Science Bulletin、Small、Optics Letters、APL Photonics等国际高水平期刊。研究工作被Nature Photonics、Molecular Cell、ACS Nano等权威杂志正面引用，并多次被Phy.org、Duke Research 等学术网站亮点报道。主持在研5项国家自然科学基金项目以及省市等科研基金项目。指导课题组学生获得深圳湾实验室主任特等奖学金（2023）、中国研究生电子设计竞赛华中赛区二等奖（2023）。

荣誉

2022  广东省高层次人才计划-青年拔尖人才

2021  深圳市高层次人才

2020  杜克大学Fitzpatrick光子学研究所杰出博后讲座奖

2019  杜克大学杰出博后提名奖

2015  上海市优秀毕业生

媒体报道

1. 人物 | 侯尚国：突破极限 “看”清微观世界的奥秘

2. Tracking Tiny Moving Targets

3. 3-D virus cam catches germs red-handed

4. Pushing the limits of microbiology: Tracking how viruses affect single cells

招聘信息

1. 博士后

2. 博士生

3. 研究助理

代表论文

1. Zhaoshuai Gao, Qian Li, Chunhai Fan*, Shangguo Hou*. Deciphering live-cell biomolecular dynamics with single-molecule fluorescence imaging. Science Bulletin. 永利娱乐城. In Press. http://doi.org/10.1016/j.scib.永利娱乐城.03.036

2. Hao Sha, Haoyang Li, Yongbing Zhang*, Shangguo Hou*. Deep learning-enhanced single-molecule spectrum imaging. APL Photonics, 2023, 8, 096102.

3. Xiufeng Zhang†, Haoyang Li†, Yue Ma†, Dongping Zhong*, and Shangguo Hou*. Study Liquid-liquid phase separation with optical microscopy: a methodology review. APL Bioengineering, 2023; 7(2): 021502. (Featured Article)

4. Shangguo Hou, Jack Exell, Kevin Welsher. Real-time 3D Single Molecule Tracking. Nature Communications, 2020, 11, 3607.

5. Shangguo Hou, Kevin Welsher. An Adaptive Real-Time 3D Single Particle Tracking Method for Monitoring Viral First Contacts. Small, 2019, 15, 1903039

6. Shangguo Hou, Xiaoqi Lang, Kevin Welsher. Robust real-time 3D single-particle tracking using a dynamically moving laser spot. Optics Letters, 2017, 42, 2390-2393.

7. Shangguo Hou†, Jianfang Chen†, Suhui Deng, Fei Wang, Qing Huang, Ya Cheng, Chunhai Fan. Improved resolution in fluorescence microscopy with the FRET pairs by time gating. Optics Express, 2015, 23, 13121-13129

8. Shangguo Hou, Le Liang, Suhui Deng, Jianfang Chen, Qing Huang, Ya Cheng, Chunhai Fan. Nanoprobes for super-resolution fluorescence imaging at the nanoscale. SCIENCE CHINA Chemistry, 2014, 57, 100-106.

9. Siddharth Patel, N Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph Griffith III, Shangguo Hou, Adam Esposito, Tatiana Ketova, Kevin Welsher, John Joyal, Orn Almarsson, Gaurav Sahay. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nature Communications, 2020, 11, 983

10. Zhichao Liu, Ying Zhu, Liming Zhang, Weiping Jiang, Yawei Liu, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou, Hongjie Zhang, Maili Liu, Chunhai Fan, Yang Tian. Structural and functional imaging of brains. SCIENCE CHINA Chemistry. 2023, 66, 324–36