研究领域

突触形成和突触功能维持的分子基础及突触障碍在神经精神疾病中的作用。

成果

张勃博士在Molecular Psychiatry (2017,永利娱乐城)、Science Advances (2022) 、Journal of Experimental Medicine (2018) 、Journal of Neuroscience (2016)等领域顶级学术期刊上发表唯一或者最后通讯作者研究论文。通讯作者论文被F1000 推荐（2 篇）或被亮点报道，受到广泛关注。张勃实验室（www.bozhanglab.org）主持国家自然科学基金委国际合作项目，优秀青年项目，以及面上项目，及省市级其它项目。

荣誉

2023  深圳市政府特殊津贴专家

2020  优秀青年科学基金项目

2019  广东省珠江人才计划青年拔尖人才项目

2019  深圳市孔雀计划人才

媒体报道

1. 央视新闻“奋斗百年路 启航新征程”采访深圳湾实验室

2. 【永利娱乐城】十年磨一剑，励志再前行

3. 凤凰卫视 | 深圳特区40年大力引才激活基础科研

4. 光明科学城国际人才街区示范点揭幕

5. 深圳湾实验室张勃喜获国家自然科学基金优青项目支持

招聘信息

1. 助理研究员

2. 博士后 

3. 研究助理

代表论文

1: Qin, L*, Liu, Z.*, Guo, S., Han, Y., Wang, X., Ren, W., Chen, J., Zhen, H., Nie, C., Xing, K., Chen, T., Südhof TC*, Sun, Y. *, Zhang, B*. (永利娱乐城). Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number. Molecular Psychiatry. （最后通讯作者）

2: Lloyd, B.A., Han, Y., Roth, R., Zhang, B., Aoto, J*. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature Communications. 14, 4706. 

3: Zhu, F. ^#, Liu, L. ^#, Li, J. ^#, Liu, B., Wang, Q., Jiao R., Xu, Y., Wang, L., Sun, S., Sun, X., Younus, M., Wang, C., Hokfel, T., Zhang, B.*, Gu, H. *, Xu, Z. *, Zhou, Z. *. (2022). Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Reports. 40(7), 16 August 2022, 111199.  (共同通讯作者)

4: Han, Y^#, Cao, R^#, Qin, L., Chen, L., Tang, A., *, Südhof, TC*, Zhang, B*. (2022) Neuroligin-3 confines AMPA-receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses. Science Advances. 8(24):eabo4173. (最后通讯作者)

5: Qin, L., Guo, S., Han, Y., Wang, X., Zhang, B*. (2020) Functional mosaic organization of neuroligins in neuronal circuits. Cellular and Molecular Life Sciences. 77, 3117-3127. (最后通讯作者)

6: Zhang, B.*,Gokce, O., Hale, D., Brose, N., Südhof, TC. (2018) Autism-associated Neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses. Journal of Experimental Medicine. 215 (6): 1543-1553 (唯一通讯作者)

7: Zhang, B.*,Seigneur, E., Wei, P., Gokce, O., Morgan, J., Südhof, TC. (2017) Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held. Molecular Psychiatry. 22, 1483–1491. [F1000 recommended] (唯一通讯作者)

8: Zhang, B.*, Südhof, TC. (2016). Neuroligins are selectively essential for NMDA-receptor signaling in cerebellar stellate interneurons. J. Neurosci. 36(35):9070-9083. [F1000 recommended]. (唯一通讯作者)

9: Zhang, B.#, Chen, L. #, Maxeiner, S., Lee, S., Gokce, O., Südhof, TC*. (2015) Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 87(4):781-96. [封面论文]