Never stop thinking
张浩岳
Adam ZHANG
分子生理学研究所
特聘研究员
zhang_adam@yiyidaolai.org
Timeline
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2021 至今
深圳湾实验室 特聘研究员
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2016-2021
美国费城儿童医院 博士后
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2011-2016
美国马里兰大学帕克分校 博士
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2007-2011
同济大学 学士
研究方向
表观遗传学,基因组学,3D基因组学,转录调控与疾病,有丝分裂,衰老
成果
1. 建立了早老症(HGPS)病人血管平滑肌细胞的体外诱导分化系统。
2. 首次阐明了早老症病人血管平滑肌细胞死亡的分子机制,为早衰症治疗提供了新思路。
3. 首次阐明了动物细胞染色质在有丝分裂之后子细胞当中的重塑过程,解析了染色质结构蛋白CTCF以及cohesin环复合体在有丝分裂后与染色质重新结合的动力学特征。为环挤压模型(loop extrusion model)在有丝分裂后染色质三维结构的重塑的调控作用提供了有力证据。
4. 阐释了有丝分裂后染色质结构重塑与基因转录重启之间的关系。
5. 阐明了染色质结构蛋白CTCF在有丝分裂后染色质结构重塑中的作用。
成果发表论文十余篇,并以第一作者身份在Nature, PNAS, Aging Cell 等杂志发表文章。并以共同作者身份在Nature Genetics, Genome Research, Cell Reports, Scientific Reports 等杂志发表文章。
有丝分裂后A/B蛋白质区域(分段)重塑过程
荣誉
2017 Charles A. Caramello Distinguished Dissertation Award, University of Maryland College Park
2014 MOCB Travel Award, University of Maryland College Park
2014 BISI Merit Student Award, University of Maryland College Park
2013 Best Poster Presentation Award. University of Maryland, School of Medicine
2011 Dean' s Fellowship, University of Maryland College Park
2011 Best Thesis Award, Tongji University
2010 China National Scholarship, Ministry of Education, China
2009 First Class Scholarship, Tongji University
2009 Shanghai Scholarship, Shanghai Education Commission, China
招聘信息
代表论文
Preprints
Zhao H., Shu L.,…Zhang, H*. Extensive mutual influences of SMC complexes shape 3D genome folding. Biorxiv, 56(6):1213-1224 (永利娱乐城). http://doi.org/10.1101/永利娱乐城.07.31.606012
Primary research publications
1. Zhao H.,…Zhang, H*. Genome folding principles uncovered in condensin-deficient mitotic chromosomes. Nature Genetics, 56(6):1213-1224 (永利娱乐城).
2. Zhang, H. et al. CTCF and transcription influence chromatin structure re-configuration after mitosis. Nat Commun 12, 5157 (2021).
3. Zhang, H. et al. Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature 576, 158-162 (2019).
4. Zhang, H. et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS One 11, e0167454 (2016).
5. Zhang, H., Xiong, Z.M. & Cao, K. Mechanisms controlling the smooth muscle cell death in progeria via downregulation of poly(ADP-ribose) polymerase 1. Proc Natl Acad Sci USA 111, E2261-70 (2014)
Review publications
1. Zhang, H. & Blobel, G.A. Genome folding dynamics during the M-to-G1-phase transition. Curr Opin Genet Dev 80, 102036 (2023).
2. Zhang H and Cao K. Mechanisms of Genome Instability in Hutchinson-Gilford Progeria. Frontiers in Biology, DOI 10.1007/s11515-016-1435-x (2016)
3. Zhang, H., Kieckhaefer, J.E. & Cao, K. Mouse models of laminopathies. Aging Cell 12, 2-10 (2013).